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Chemical structure of LXS196

GC32811

LXS196

Also known as 3-amino-N-[3-(4-amino-4-methylpiperidin-1-yl)-2-pyridinyl]-6-[3-(trifluoromethyl)-2-pyridinyl]pyrazine-2-carboxamide

LXS196 (LXS196) is a potent, selective and orally active protein kinase C (PKC) inhibitor, with IC50 values of 1·9 nM, 0·4 nM and 3·1 μM for PKCα, PKCθ and GSK3β, respectively· LXS196 has the potential for uveal melanoma research

ChemicalCAS1874276-76-2MW472.47FormulaC22H23F3N8O
CAS number
1874276-76-2
Molecular weight
472.47
Formula
C22H23F3N8O
Solubility
DMSO ： ≥ 100 mg/mL (211·65 mM)
InChIKey
XXJXHXJWQSCNPX-UHFFFAOYSA-N
Catalogue number
GC32811
Brand
GLPBIO
Computed properties PubChem CID 118873253 · XLogP 1.9 · TPSA 136 Ų · H-bond donors 3
XLogP
1.9
TPSA
136 Ų
H-bond donors
3
H-bond acceptors
11
Rotatable bonds
4
Heavy atoms
34

SMILES CC1(CCN(CC1)C2=C(N=CC=C2)NC(=O)C3=NC(=CN=C3N)C4=C(C=CC=N4)C(F)(F)F)N

Computed descriptors from PubChem (CID 118873253), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.