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Chemical structure of KP-457

GC32452

KP-457

Also known as N-[2-(4-but-2-ynoxyphenyl)sulfonyl-1-[4-(methanesulfonamidomethyl)phenyl]ethyl]-N-hydroxyformamide

KP‐457 is a selective ADAM17 inhibitor, which has a reverse-hydroxamate structure

ChemicalCAS1365803-52-6MW480.55FormulaC21H24N2O7S2
CAS number
1365803-52-6
Molecular weight
480.55
Formula
C21H24N2O7S2
Solubility
DMSO ： 125 mg/mL (260·12 mM)
InChIKey
VIWDSTUVCAZZDF-UHFFFAOYSA-N
Catalogue number
GC32452
Brand
GLPBIO
Computed properties PubChem CID 56598918 · XLogP 1.2 · TPSA 147 Ų · H-bond donors 2
XLogP
1.2
TPSA
147 Ų
H-bond donors
2
H-bond acceptors
8
Rotatable bonds
10
Heavy atoms
32

SMILES CC#CCOC1=CC=C(C=C1)S(=O)(=O)CC(C2=CC=C(C=C2)CNS(=O)(=O)C)N(C=O)O

Computed descriptors from PubChem (CID 56598918), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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