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Chemical structure of PCO371

GC32415

PCO371

Also known as 1-[3,5-dimethyl-4-[2-[[4-oxo-2-[4-(trifluoromethoxy)phenyl]-1,3,8-triazaspiro[4.5]dec-1-en-8-yl]sulfonyl]ethyl]phenyl]-5,5-dimethylimidazolidine-2,4-dione

PCO371 is an orally active full agonist of parathyroid hormone receptor 1 (PTHR1), with no effect on PTH type 2 receptor

ChemicalCAS1613373-33-3MW635.65FormulaC29H32F3N5O6S
CAS number
1613373-33-3
Molecular weight
635.65
Formula
C29H32F3N5O6S
Solubility
DMSO: 125 mg/mL (196·65 mM)
InChIKey
LDZJFVOUPUFOHX-UHFFFAOYSA-N
Catalogue number
GC32415
Brand
GLPBIO
Computed properties PubChem CID 76283707 · XLogP 3.7 · TPSA 146 Ų · H-bond donors 2
XLogP
3.7
TPSA
146 Ų
H-bond donors
2
H-bond acceptors
11
Rotatable bonds
7
Heavy atoms
44

SMILES CC1=CC(=CC(=C1CCS(=O)(=O)N2CCC3(CC2)C(=O)NC(=N3)C4=CC=C(C=C4)OC(F)(F)F)C)N5C(=O)NC(=O)C5(C)C

Computed descriptors from PubChem (CID 76283707), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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