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Chemical structure of PCNA-I1

GC44577

PCNA-I1

Also known as N-[(E)-(1-hydroxynaphthalen-2-yl)methylideneamino]-3-methylthiophene-2-carboxamide

PCNA-I1 is an inhibitor of proliferating cell nuclear antigen (PCNA) that binds to PCNA trimers (Kd = 0·41 μM) and dose-dependently reduces the level of PCNA associated with chromatin in PC3 cells

ChemicalCAS444930-42-1MW310.4FormulaC17H14N2O2S
CAS number
444930-42-1
Molecular weight
310.4
Formula
C17H14N2O2S
Solubility
DMF： 10 mg/ml,DMSO： 10 mg/ml,DMSO：PBS(pH 7·2) (1：3)： 0·25 mg/ml
InChIKey
NZWTWRNHYZNWNW-VCHYOVAHSA-N
Catalogue number
GC44577
Brand
GLPBIO
Computed properties PubChem CID 135533619 · XLogP 4.1 · TPSA 89.9 Ų · H-bond donors 2
XLogP
4.1
TPSA
89.9 Ų
H-bond donors
2
H-bond acceptors
4
Rotatable bonds
3
Heavy atoms
22

SMILES CC1=C(SC=C1)C(=O)N/N=C/C2=C(C3=CC=CC=C3C=C2)O

Computed descriptors from PubChem (CID 135533619), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.