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Chemical structure of VTX-27

GC31912

VTX-27

Also known as (2R)-2-[(2S)-4-[3-chloro-5-fluoro-6-(2H-pyrazolo[3,4-b]pyridin-3-yl)-2-pyridinyl]piperazin-2-yl]-3-methylbutan-2-ol

VTX-27 is a selective protein kinase C θ (PKC θ) inhibitor, with Kis of 0·08 nM and 16 nM for PKC θ and PKC δ

ChemicalCAS1321924-70-2MW418.9FormulaC20H24ClFN6O
CAS number
1321924-70-2
Molecular weight
418.9
Formula
C20H24ClFN6O
Solubility
DMSO ： 125 mg/mL (298·40 mM)
InChIKey
HXWARSZQGAFXJM-MGPUTAFESA-N
Catalogue number
GC31912
Brand
GLPBIO
Computed properties PubChem CID 53354074 · XLogP 2.9 · TPSA 90 Ų · H-bond donors 3
XLogP
2.9
TPSA
90 Ų
H-bond donors
3
H-bond acceptors
7
Rotatable bonds
4
Heavy atoms
29

SMILES CC(C)[C@](C)([C@@H]1CN(CCN1)C2=C(C=C(C(=N2)C3=C4C=CC=NC4=NN3)F)Cl)O

Computed descriptors from PubChem (CID 53354074), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.