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Chemical structure of ROCK2-IN-2

GC31883

ROCK2-IN-2

Also known as N-(1H-indazol-5-yl)-5-[3-(1,3-oxazol-2-yl)phenyl]-1,3,4-thiadiazol-2-amine

ROCK2-IN-2 is a selective ROCK2 inhibitor extracted from patent US20180093978A1, Compound A-30, has an IC50 of ＜1 μM

ChemicalCAS1995065-79-6MW360.39FormulaC18H12N6OS
CAS number
1995065-79-6
Molecular weight
360.39
Formula
C18H12N6OS
Solubility
DMSO ： 100 mg/mL (277·48 mM; Need ultrasonic)
InChIKey
WFSHRQCWPPIEIB-UHFFFAOYSA-N
Catalogue number
GC31883
Brand
GLPBIO
Computed properties PubChem CID 122507549 · XLogP 3.6 · TPSA 121 Ų · H-bond donors 2
XLogP
3.6
TPSA
121 Ų
H-bond donors
2
H-bond acceptors
7
Rotatable bonds
4
Heavy atoms
26

SMILES C1=CC(=CC(=C1)C2=NN=C(S2)NC3=CC4=C(C=C3)NN=C4)C5=NC=CO5

Computed descriptors from PubChem (CID 122507549), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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