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Chemical structure of JNJ-54175446

GC31098

JNJ-54175446

Also known as [2-chloro-3-(trifluoromethyl)phenyl]-[(4R)-1-(5-fluoropyrimidin-2-yl)-4-methyl-6,7-dihydro-4H-triazolo[4,5-c]pyridin-5-yl]methanone

JNJ-54175446 is a potent and selective brain penetrant P2X7 receptor antagonist, with pIC50s of 8·46 and 8·81 for hP2X7 receptor and rP2X7 receptor, respectively

ChemicalCAS1627902-21-9MW440.78FormulaC18H13ClF4N6O
CAS number
1627902-21-9
Molecular weight
440.78
Formula
C18H13ClF4N6O
Solubility
DMSO： 62·5 mg/mL (141·79 mM)
InChIKey
CWFVVQFVGMFTBD-SECBINFHSA-N
Catalogue number
GC31098
Brand
GLPBIO
Computed properties PubChem CID 90409366 · XLogP 3 · TPSA 76.8 Ų · H-bond donors 0
XLogP
3
TPSA
76.8 Ų
H-bond donors
0
H-bond acceptors
9
Rotatable bonds
2
Heavy atoms
30

SMILES C[C@@H]1C2=C(CCN1C(=O)C3=C(C(=CC=C3)C(F)(F)F)Cl)N(N=N2)C4=NC=C(C=N4)F

Computed descriptors from PubChem (CID 90409366), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.