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Chemical structure of TRPV antagonist 1

GC30725

TRPV antagonist 1

Also known as 7-[(E)-2-[2-(cyclopropylmethoxy)-3-methoxyphenyl]ethenyl]-6-[4-(trifluoromethoxy)phenyl]-[1,3]thiazolo[3,2-a]pyrimidin-5-one

TRPV antagonist 1 is a transient receptor potential vanilloid (TRPV) antagonist, with an IC50 of < 250 nM

ChemicalCAS1192871-27-4MW514.52FormulaC26H21F3N2O4S
CAS number
1192871-27-4
Molecular weight
514.52
Formula
C26H21F3N2O4S
Solubility
Soluble in DMSO
InChIKey
AQYDUQPBWUAJJS-FMIVXFBMSA-N
Catalogue number
GC30725
Brand
GLPBIO
Computed properties PubChem CID 44247573 · XLogP 6 · TPSA 85.7 Ų · H-bond donors 0
XLogP
6
TPSA
85.7 Ų
H-bond donors
0
H-bond acceptors
9
Rotatable bonds
8
Heavy atoms
36

SMILES COC1=CC=CC(=C1OCC2CC2)/C=C/C3=C(C(=O)N4C=CSC4=N3)C5=CC=C(C=C5)OC(F)(F)F

Computed descriptors from PubChem (CID 44247573), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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