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Chemical structure of DC10539

GC19493

DC10539

Also known as 2-[(3R,5S)-3,5-dimethylpiperazin-1-yl]benzimidazolo[1,2-a][1,8]naphthyridine-6-carbonitrile

DC10539 is a RNA polymerase 1 (POL1, also known as Pol I) inhibitor with an IC50 of less than 0·5 uM· DC10539 inhibits ribosome biogenesis by inhibiting POL1 transcription

ChemicalCAS1822358-25-7MW356.42FormulaC21H20N6
CAS number
1822358-25-7
Molecular weight
356.42
Formula
C21H20N6
Solubility
Soluble in DMSO
InChIKey
HFQPEPQECNSOFF-OKILXGFUSA-N
Catalogue number
GC19493
Brand
GLPBIO
Computed properties PubChem CID 118509873 · XLogP 4.2 · TPSA 69.3 Ų · H-bond donors 1
XLogP
4.2
TPSA
69.3 Ų
H-bond donors
1
H-bond acceptors
5
Rotatable bonds
1
Heavy atoms
27

SMILES C[C@@H]1CN(C[C@@H](N1)C)C2=NC3=C(C=C2)C=C(C4=NC5=CC=CC=C5N34)C#N

Computed descriptors from PubChem (CID 118509873), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.