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Chemical structure of RO8994

GC19312

RO8994

Also known as (2'R,3R,3'S,5'S)-N-(4-carbamoyl-2-methoxyphenyl)-6-chloro-3'-(3-chloro-2-fluorophenyl)-5'-(2,2-dimethylpropyl)-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamide

RO8994 is a highly potent and selective series of spiroindolinone small-molecule MDM2 inhibitor, with IC50 of 5 nM (HTRF binding assays) and 20 nM (MTT proliferation assays)

ChemicalCAS1309684-94-3MW613.51FormulaC31H31Cl2FN4O4
CAS number
1309684-94-3
Molecular weight
613.51
Formula
C31H31Cl2FN4O4
Solubility
DMSO ： ≥ 45 mg/mL (73·35 mM)
InChIKey
MURAVORBGFDSMA-ISKXDESKSA-N
Catalogue number
GC19312
Brand
GLPBIO
Computed properties PubChem CID 53238217 · XLogP 5 · TPSA 123 Ų · H-bond donors 4
XLogP
5
TPSA
123 Ų
H-bond donors
4
H-bond acceptors
6
Rotatable bonds
7
Heavy atoms
42

SMILES CC(C)(C)C[C@H]1[C@@]2([C@H]([C@@H](N1)C(=O)NC3=C(C=C(C=C3)C(=O)N)OC)C4=C(C(=CC=C4)Cl)F)C5=C(C=C(C=C5)Cl)NC2=O

Computed descriptors from PubChem (CID 53238217), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.