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Chemical structure of KIRA6

GC19212

KIRA6

Also known as 1-[4-(8-amino-3-tert-butylimidazo[1,5-a]pyrazin-1-yl)naphthalen-1-yl]-3-[3-(trifluoromethyl)phenyl]urea

KIRA6 allosterically inhibits IRE1α RNase kinase activity with an IC50 of 0·6 uM

ChemicalCAS1589527-65-0MW518.53FormulaC28H25F3N6O
CAS number
1589527-65-0
Molecular weight
518.53
Formula
C28H25F3N6O
Solubility
DMSO ： ≥ 5 mg/mL (9·64 mM);Ethanol ： 2 mg/mL (3·86 mM)
InChIKey
NOHQEAFAESMMDX-UHFFFAOYSA-N
Catalogue number
GC19212
Brand
GLPBIO
Computed properties PubChem CID 73425700 · XLogP 6.5 · TPSA 97.3 Ų · H-bond donors 3
XLogP
6.5
TPSA
97.3 Ų
H-bond donors
3
H-bond acceptors
7
Rotatable bonds
4
Heavy atoms
38

SMILES CC(C)(C)C1=NC(=C2N1C=CN=C2N)C3=CC=C(C4=CC=CC=C43)NC(=O)NC5=CC=CC(=C5)C(F)(F)F

Computed descriptors from PubChem (CID 73425700), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.