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Chemical structure of JNJ-42153605

GC19207

JNJ-42153605

Also known as 3-(cyclopropylmethyl)-7-(4-phenylpiperidin-1-yl)-8-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine

JNJ-42153605 is a positive allosteric modulator of the metabotropic glutamate 2 (mGlu2) receptor with an EC50 of 17 nM

ChemicalCAS1254977-87-1MW400.44FormulaC22H23F3N4
CAS number
1254977-87-1
Molecular weight
400.44
Formula
C22H23F3N4
Solubility
DMF： 30 mg/ml,DMF：PBS (pH 7·2) (1：3)： 0·25 mg/ml
InChIKey
BQAVZGJJQFJSMW-UHFFFAOYSA-N
Catalogue number
GC19207
Brand
GLPBIO
Computed properties PubChem CID 49765871 · XLogP 5.8 · TPSA 33.4 Ų · H-bond donors 0
XLogP
5.8
TPSA
33.4 Ų
H-bond donors
0
H-bond acceptors
6
Rotatable bonds
4
Heavy atoms
29

SMILES C1CC1CC2=NN=C3N2C=CC(=C3C(F)(F)F)N4CCC(CC4)C5=CC=CC=C5

Computed descriptors from PubChem (CID 49765871), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.