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Chemical structure of CEP-40783

GC19102

CEP-40783

Also known as N-[4-(6,7-dimethoxyquinolin-4-yl)oxy-3-fluorophenyl]-3-(4-fluorophenyl)-2,4-dioxo-1-propan-2-ylpyrimidine-5-carboxamide

CEP-40783 is a potent, selective and orally available inhibitor of AXL and c-Met with IC50 values of 7 nM and 12 nM, respectively

ChemicalCAS1437321-24-8MW588.56FormulaC31H26F2N4O6
CAS number
1437321-24-8
Molecular weight
588.56
Formula
C31H26F2N4O6
Solubility
DMSO ： 7·6 mg/mL (12·91 mM)
InChIKey
FKCWHHYUMFGOPY-UHFFFAOYSA-N
Catalogue number
GC19102
Brand
GLPBIO
Computed properties PubChem CID 71576419 · XLogP 4.7 · TPSA 110 Ų · H-bond donors 1
XLogP
4.7
TPSA
110 Ų
H-bond donors
1
H-bond acceptors
9
Rotatable bonds
8
Heavy atoms
43

SMILES CC(C)N1C=C(C(=O)N(C1=O)C2=CC=C(C=C2)F)C(=O)NC3=CC(=C(C=C3)OC4=C5C=C(C(=CC5=NC=C4)OC)OC)F

Computed descriptors from PubChem (CID 71576419), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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