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Chemical structure of CEP-32496

GC16845

CEP-32496

Also known as 1-[3-(6,7-dimethoxyquinazolin-4-yl)oxyphenyl]-3-[5-(1,1,1-trifluoro-2-methylpropan-2-yl)-1,2-oxazol-3-yl]urea

CEP-32496 (CEP-32496; RXDX-105) is a highly potent and orally efficacious inhibitor of BRAFV600E with a Kd of 14 nM

ChemicalCAS1188910-76-0MW517.46FormulaC24H22F3N5O5
CAS number
1188910-76-0
Molecular weight
517.46
Formula
C24H22F3N5O5
Solubility
≥ 25·85mg/mL in DMSO
InChIKey
DKNUPRMJNUQNHR-UHFFFAOYSA-N
Catalogue number
GC16845
Brand
GLPBIO
Computed properties PubChem CID 56846693 · XLogP 5 · TPSA 121 Ų · H-bond donors 2
XLogP
5
TPSA
121 Ų
H-bond donors
2
H-bond acceptors
11
Rotatable bonds
7
Heavy atoms
37

SMILES CC(C)(C1=CC(=NO1)NC(=O)NC2=CC(=CC=C2)OC3=NC=NC4=CC(=C(C=C43)OC)OC)C(F)(F)F

Computed descriptors from PubChem (CID 56846693), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.