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Chemical structure of AF3485

GC18882

AF3485

Also known as N-[9-(2-hydroxyethyl)carbazol-3-yl]-2-(trifluoromethyl)benzamide

AF3485 is a selective 3-aminocarbazole inhibitor of mPGES-1, blocking the synthesis of PGE2 but not PGF2α in A549 cells stimulated with IL-1β (IC50s = 2·9 and >100 µM, respectively)

ChemicalCAS1195786-61-8MW398.4FormulaC22H17F3N2O2
CAS number
1195786-61-8
Molecular weight
398.4
Formula
C22H17F3N2O2
Solubility
DMF： 30 mg/ml,DMF：PBS (pH 7·2); (1：7)： 0·1 mg/ml,DMSO： 10 mg/ml,Ethanol： 0·3 mg/ml
InChIKey
RXVOFPXZHVKZIL-UHFFFAOYSA-N
Catalogue number
GC18882
Brand
GLPBIO
Computed properties PubChem CID 44469536 · XLogP 4.3 · TPSA 54.3 Ų · H-bond donors 2
XLogP
4.3
TPSA
54.3 Ų
H-bond donors
2
H-bond acceptors
5
Rotatable bonds
4
Heavy atoms
29

SMILES C1=CC=C2C(=C1)C3=C(N2CCO)C=CC(=C3)NC(=O)C4=CC=CC=C4C(F)(F)F

Computed descriptors from PubChem (CID 44469536), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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