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Chemical structure of Ac-Nle-Pro-Nle-Asp-AMC

GC18371

Ac-Nle-Pro-Nle-Asp-AMC

Also known as (3S)-3-[[(2S)-2-[[(2S)-1-[(2S)-2-acetamidohexanoyl]pyrrolidine-2-carbonyl]amino]hexanoyl]amino]-4-[(4-methyl-2-oxochromen-7-yl)amino]-4-oxobutanoic acid

Ac-Nle-Pro-Nle-Asp-AMC is a substrate for proteasomes that is cleaved by the caspase-like site, also known as postglutamyl peptide hydrolase (PGPH), with specific activities of 113 and 6·6 nmol/min/mg by the 26S (rabbit muscle) and 20S (yeast) proteasomes, respectively

ChemicalCAS355140-49-7MW655.7FormulaC33H45N5O9
CAS number
355140-49-7
Molecular weight
655.7
Formula
C33H45N5O9
Solubility
20mg/ml in ethanol; 30mg/ml in DMSO
InChIKey
WPTAROWBMZVECB-CQJMVLFOSA-N
Catalogue number
GC18371
Brand
GLPBIO
Computed properties PubChem CID 131698166 · XLogP 2.3 · TPSA 200 Ų · H-bond donors 5
XLogP
2.3
TPSA
200 Ų
H-bond donors
5
H-bond acceptors
9
Rotatable bonds
16
Heavy atoms
47

SMILES CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)NC1=CC2=C(C=C1)C(=CC(=O)O2)C)NC(=O)[C@@H]3CCCN3C(=O)[C@H](CCCC)NC(=O)C

Computed descriptors from PubChem (CID 131698166), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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