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Chemical structure of Leptomycin A

GC18345

Leptomycin A

Also known as (2E,10E,12E,16E,18E)-6-hydroxy-3,5,7,9,11,15,17-heptamethyl-19-(3-methyl-6-oxo-2,3-dihydropyran-2-yl)-8-oxononadeca-2,10,12,16,18-pentaenoic acid

Leptomycin A is an inhibitor of CRM1 (exportin 1) that blocks CRM1 interaction with nuclear export signals, preventing the nuclear export of a broad range of proteins

ChemicalCAS87081-36-5MW526.7FormulaC32H46O6
CAS number
87081-36-5
Molecular weight
526.7
Formula
C32H46O6
Solubility
Ethanol： Soluble,Methanol： Soluble
InChIKey
QECBVZBMGUAZDL-DLWOFZAMSA-N
Catalogue number
GC18345
Brand
GLPBIO
Computed properties PubChem CID 5384875 · XLogP 7.4 · TPSA 101 Ų · H-bond donors 2
XLogP
7.4
TPSA
101 Ų
H-bond donors
2
H-bond acceptors
6
Rotatable bonds
14
Heavy atoms
38

SMILES CC1C=CC(=O)OC1/C=C/C(=C/C(C)C/C=C/C(=C/C(C)C(=O)C(C)C(C(C)C/C(=C/C(=O)O)/C)O)/C)/C

Computed descriptors from PubChem (CID 5384875), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.