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Chemical structure of AGK 2

GC17881

AGK 2

Also known as 2-cyano-3-[5-(2,5-dichlorophenyl)furan-2-yl]-N-quinolin-5-ylprop-2-enamide

AGK2 is a selective SIRT2 inhibitor, with an IC50 of 3·5 µM· AGK2 inhibits SIRT1 and SIRT3 with IC50 of 30 and 91 µM, respectively

ChemicalCAS304896-28-4MW434.27FormulaC23H13Cl2N3O2
CAS number
304896-28-4
Molecular weight
434.27
Formula
C23H13Cl2N3O2
Solubility
≥ 9·3mg/mL in DMSO
InChIKey
SVENPFFEMUOOGK-UHFFFAOYSA-N
Catalogue number
GC17881
Brand
GLPBIO
Computed properties PubChem CID 1183107 · XLogP 5.9 · TPSA 78.9 Ų · H-bond donors 1
XLogP
5.9
TPSA
78.9 Ų
H-bond donors
1
H-bond acceptors
4
Rotatable bonds
4
Heavy atoms
30

SMILES C1=CC2=C(C=CC=N2)C(=C1)NC(=O)C(=CC3=CC=C(O3)C4=C(C=CC(=C4)Cl)Cl)C#N

Computed descriptors from PubChem (CID 1183107), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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