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Chemical structure of AG-18

GC17647

AG-18

Also known as 2-[(3,4-dihydroxyphenyl)methylidene]propanedinitrile

AG-18 (Tyrphostin A23) is an EGFR inhibitor with an IC50 and Kiof 35 and 11 μM, respectively

ChemicalCAS118409-57-7MW186.17FormulaC10H6N2O2
CAS number
118409-57-7
Molecular weight
186.17
Formula
C10H6N2O2
Solubility
≥ 9·3mg/mL in DMSO
InChIKey
VTJXFTPMFYAJJU-UHFFFAOYSA-N
Catalogue number
GC17647
Brand
GLPBIO
Computed properties PubChem CID 2052 · XLogP 1.3 · TPSA 88 Ų · H-bond donors 2
XLogP
1.3
TPSA
88 Ų
H-bond donors
2
H-bond acceptors
4
Rotatable bonds
1
Heavy atoms
14

SMILES C1=CC(=C(C=C1C=C(C#N)C#N)O)O

Computed descriptors from PubChem (CID 2052), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

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