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Chemical structure of VRT752271

GC17031

VRT752271

Also known as N-[(1S)-1-(3-chlorophenyl)-2-hydroxyethyl]-4-[5-chloro-2-(propan-2-ylamino)-4-pyridinyl]-1H-pyrrole-2-carboxamide

VRT752271 (BVD-523; VRT752271) is a potent, orally active, highly selective, ATP-competitive and reversible covalent inhibitor of ERK1/2 kinases, with an IC50 of ＜0·3 nM against ERK2· VRT752271 (BVD-523; VRT752271) inhibits the phosphorylated ERK2 (pERK) and downstream kinase RSK (pRSK) in an A375 melanoma cell line

ChemicalCAS869886-67-9MW433.33FormulaC21H22Cl2N4O2
CAS number
869886-67-9
Molecular weight
433.33
Formula
C21H22Cl2N4O2
Solubility
≥ 43·3mg/mL in DMSO
InChIKey
KSERXGMCDHOLSS-LJQANCHMSA-N
Catalogue number
GC17031
Brand
GLPBIO
Computed properties PubChem CID 11719003 · XLogP 4.1 · TPSA 90 Ų · H-bond donors 4
XLogP
4.1
TPSA
90 Ų
H-bond donors
4
H-bond acceptors
4
Rotatable bonds
7
Heavy atoms
29

SMILES CC(C)NC1=NC=C(C(=C1)C2=CNC(=C2)C(=O)N[C@H](CO)C3=CC(=CC=C3)Cl)Cl

Computed descriptors from PubChem (CID 11719003), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.