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Chemical structure of TAE226(NVP-TAE226)

GC16821

TAE226(NVP-TAE226)

Also known as 2-[[5-chloro-2-(2-methoxy-4-morpholin-4-ylanilino)pyrimidin-4-yl]amino]-N-methylbenzamide

TAE226(NVP-TAE226) (TAE226) is a potent and ATP-competitive dual FAK and IGF-1R inhibitor with IC50s of 5·5 nM and 140 nM, respectively

ChemicalCAS761437-28-9MW468.94FormulaC23H25ClN6O3
CAS number
761437-28-9
Molecular weight
468.94
Formula
C23H25ClN6O3
Solubility
≥ 23·45mg/mL in DMSO
InChIKey
UYJNQQDJUOUFQJ-UHFFFAOYSA-N
Catalogue number
GC16821
Brand
GLPBIO
Computed properties PubChem CID 9934347 · XLogP 4.1 · TPSA 101 Ų · H-bond donors 3
XLogP
4.1
TPSA
101 Ų
H-bond donors
3
H-bond acceptors
8
Rotatable bonds
7
Heavy atoms
33

SMILES CNC(=O)C1=CC=CC=C1NC2=NC(=NC=C2Cl)NC3=C(C=C(C=C3)N4CCOCC4)OC

Computed descriptors from PubChem (CID 9934347), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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