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Chemical structure of Sivelestat

GC16724

Sivelestat

Also listed as Sivelestat (ONO-5046)

Sivelestat (ONO-5046) (EI546) is a competitive inhibitor of human neutrophil elastase, with an IC50 of 44 nM and a Ki of 200 nM· Sivelestat (ONO-5046) (EI546) has the potential for the study of acute lung injury/acute respiratory distress syndrome or disseminated intravascular coagulation in COVID-19

ChemicalCAS127373-66-4MW434.46FormulaC20H22N2O7S
CAS number
127373-66-4
Molecular weight
434.46
Formula
C20H22N2O7S
Solubility
≥ 43·4mg/mL in DMSO
InChIKey
BTGNGJJLZOIYID-UHFFFAOYSA-N
Catalogue number
GC16724
Brand
GLPBIO
Computed properties PubChem CID 107706 · XLogP 3 · TPSA 147 Ų · H-bond donors 3
XLogP
3
TPSA
147 Ų
H-bond donors
3
H-bond acceptors
8
Rotatable bonds
9
Heavy atoms
30

SMILES CC(C)(C)C(=O)OC1=CC=C(C=C1)S(=O)(=O)NC2=CC=CC=C2C(=O)NCC(=O)O

Computed descriptors from PubChem (CID 107706), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.