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Chemical structure of LGX818

GC16576

LGX818

Also known as methyl N-[(2S)-1-[[4-[3-[5-chloro-2-fluoro-3-(methanesulfonamido)phenyl]-1-propan-2-ylpyrazol-4-yl]pyrimidin-2-yl]amino]propan-2-yl]carbamate

LGX818 (LGX818) is a highly potent BRAF inhibitor with selective anti-proliferative and apoptotic activity in cells expressing BRAFV600E (EC50=4 nM)

ChemicalCAS1269440-17-6MW540.01FormulaC22H27ClFN7O4S
CAS number
1269440-17-6
Molecular weight
540.01
Formula
C22H27ClFN7O4S
Solubility
DMF： 25 mg/ml,DMF：PBS(pH 7·2)(1：1)： 0·5 mg/ml,DMSO： 20 mg/ml,Ethanol： 15 mg/ml
InChIKey
CMJCXYNUCSMDBY-ZDUSSCGKSA-N
Catalogue number
GC16576
Brand
GLPBIO
Computed properties PubChem CID 50922675 · XLogP 2.7 · TPSA 149 Ų · H-bond donors 3
XLogP
2.7
TPSA
149 Ų
H-bond donors
3
H-bond acceptors
10
Rotatable bonds
10
Heavy atoms
36

SMILES C[C@@H](CNC1=NC=CC(=N1)C2=CN(N=C2C3=C(C(=CC(=C3)Cl)NS(=O)(=O)C)F)C(C)C)NC(=O)OC

Computed descriptors from PubChem (CID 50922675), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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