GC16145
NVP-BGT226
Also known as (Z)-but-2-enedioic acid;8-(6-methoxy-3-pyridinyl)-3-methyl-1-[4-piperazin-1-yl-3-(trifluoromethyl)phenyl]imidazo[4,5-c]quinolin-2-one
BGT226 (NVP-NVP-BGT226) is a PI3K (with IC50s of 4 nM, 63 nM and 38 nM for PI3Kα, PI3Kβ and PI3Kγ) /mTOR dual inhibitor which displays potent growth-inhibitory activity against human head and neck cancer cells
ChemicalCAS1245537-68-1MW650.6FormulaC28H25F3N6O2·C4H4O4
- CAS number
- 1245537-68-1
- Molecular weight
- 650.6
- Formula
- C28H25F3N6O2·C4H4O4
- Solubility
- ≥ 16·275mg/mL in DMSO with gentle warming
- InChIKey
- YUXMAKUNSXIEKN-BTJKTKAUSA-N
- Catalogue number
- GC16145
- Brand
- GLPBIO
Computed properties PubChem CID 57336745 · TPSA 148 Ų · H-bond donors 3 · H-bond acceptors 13
- TPSA
- 148 Ų
- H-bond donors
- 3
- H-bond acceptors
- 13
- Rotatable bonds
- 6
- Heavy atoms
- 47
SMILES CN1C2=CN=C3C=CC(=CC3=C2N(C1=O)C4=CC(=C(C=C4)N5CCNCC5)C(F)(F)F)C6=CN=C(C=C6)OC.C(=C\C(=O)O)\C(=O)O
Computed descriptors from PubChem (CID 57336745), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.
Ordering in Israel
- Lead time
- Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
- Pricing
- Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
- Documents
- Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
- Who we serve
- Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.
- Questions
- WhatsApp · +972-55-990-7576 · orders@labo.co.il