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Chemical structure of ML221

GC14855

ML221

Also known as [4-oxo-6-(pyrimidin-2-ylsulfanylmethyl)pyran-3-yl] 4-nitrobenzoate

ML221 is a potent apelin (APJ) functional antagonist, inhibiting apelin-13-mediated activation of APJ, with IC50s of 0·70 μM in the cAMP assay, and 1·75 μM in the β-arrestin assay, and EC80 of 10 nM in both assays

ChemicalCAS877636-42-5MW385.35FormulaC17H11N3O6S
CAS number
877636-42-5
Molecular weight
385.35
Formula
C17H11N3O6S
Solubility
DMF： 10 mg/ml,DMF：PBS (pH 7·2) (1：30)： 0·03 mg/ml,DMSO： 1 mg/ml
InChIKey
UASIRTUMPRQVFY-UHFFFAOYSA-N
Catalogue number
GC14855
Brand
GLPBIO
Computed properties PubChem CID 7217941 · XLogP 2.2 · TPSA 150 Ų · H-bond donors 0
XLogP
2.2
TPSA
150 Ų
H-bond donors
0
H-bond acceptors
9
Rotatable bonds
6
Heavy atoms
27

SMILES C1=CN=C(N=C1)SCC2=CC(=O)C(=CO2)OC(=O)C3=CC=C(C=C3)[N+](=O)[O-]

Computed descriptors from PubChem (CID 7217941), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.