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Chemical structure of SB705498

GC14580

SB705498

Also known as 1-(2-bromophenyl)-3-[(3R)-1-[5-(trifluoromethyl)-2-pyridinyl]pyrrolidin-3-yl]urea

SB705498 is an orally bioavailable, competitive antagonist of the capsaicin-mediated of TRPV1 receptors (pKis = 7·6; 7·5; and 7·3 for human, rat, and guinea pig, respectively)·SB705498 rapidly and reversibly inhibits capsaicin-, acid-, or heat-mediated activation of human TRPV1

ChemicalCAS501951-42-4MW429.23FormulaC17H16BrF3N4O
CAS number
501951-42-4
Molecular weight
429.23
Formula
C17H16BrF3N4O
Solubility
≥ 14·5mg/mL in DMSO
InChIKey
JYILLRHXRVTRSH-GFCCVEGCSA-N
Catalogue number
GC14580
Brand
GLPBIO
Computed properties PubChem CID 9910486 · XLogP 3.8 · TPSA 57.3 Ų · H-bond donors 2
XLogP
3.8
TPSA
57.3 Ų
H-bond donors
2
H-bond acceptors
6
Rotatable bonds
3
Heavy atoms
26

SMILES C1CN(C[C@@H]1NC(=O)NC2=CC=CC=C2Br)C3=NC=C(C=C3)C(F)(F)F

Computed descriptors from PubChem (CID 9910486), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.