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Chemical structure of SB525334

GC14349

SB525334

Also known as 6-[2-tert-butyl-5-(6-methyl-2-pyridinyl)-1H-imidazol-4-yl]quinoxaline

SB525334 has been characterized as a potent and selective inhibitor of the transforming growth factor-beta1 (TGF-beta1) receptor, activin receptor-like kinase (ALK5)· SB525334 inhibited ALK5 kinase activity with an IC50 of 14·3nM

ChemicalCAS356559-20-1MW343.42FormulaC21H21N5
CAS number
356559-20-1
Molecular weight
343.42
Formula
C21H21N5
Solubility
≥ 34·3mg/mL in DMSO, ≥ 23·8 mg/mL in EtOH
InChIKey
DKPQHFZUICCZHF-UHFFFAOYSA-N
Catalogue number
GC14349
Brand
GLPBIO
Computed properties PubChem CID 9967941 · XLogP 3.7 · TPSA 67.4 Ų · H-bond donors 1
XLogP
3.7
TPSA
67.4 Ų
H-bond donors
1
H-bond acceptors
4
Rotatable bonds
3
Heavy atoms
26

SMILES CC1=NC(=CC=C1)C2=C(N=C(N2)C(C)(C)C)C3=CC4=NC=CN=C4C=C3

Computed descriptors from PubChem (CID 9967941), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

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