Loading...
Chemical structure of LDK378

GC14552

LDK378

Also known as 5-chloro-2-N-(5-methyl-4-piperidin-4-yl-2-propan-2-yloxyphenyl)-4-N-(2-propan-2-ylsulfonylphenyl)pyrimidine-2,4-diamine

LDK378 (LDK378) is a selective, orally bioavailable, and ATP-competitive ALK tyrosine kinase inhibitor with an IC50 of 200 pM

ChemicalCAS1032900-25-6MW558.14FormulaC28H36ClN5O3S
CAS number
1032900-25-6
Molecular weight
558.14
Formula
C28H36ClN5O3S
Solubility
DMSO ： 5·6 mg/mL (10·03 mM; Need ultrasonic)
InChIKey
VERWOWGGCGHDQE-UHFFFAOYSA-N
Catalogue number
GC14552
Brand
GLPBIO
Computed properties PubChem CID 57379345 · XLogP 6.4 · TPSA 114 Ų · H-bond donors 3
XLogP
6.4
TPSA
114 Ų
H-bond donors
3
H-bond acceptors
8
Rotatable bonds
9
Heavy atoms
38

SMILES CC1=CC(=C(C=C1C2CCNCC2)OC(C)C)NC3=NC=C(C(=N3)NC4=CC=CC=C4S(=O)(=O)C(C)C)Cl

Computed descriptors from PubChem (CID 57379345), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.