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Chemical structure of K03861

GC14230

K03861

Also known as 1-[4-(2-aminopyrimidin-4-yl)oxyphenyl]-3-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]urea

K03861 (K03861) is a type II CDK2 inhibitor with Kd of 8·2 nM· K03861 (K03861) inhibits CDK2 activity by competing with binding of activating cyclins

ChemicalCAS853299-07-7MW501.5FormulaC24H26F3N7O2
CAS number
853299-07-7
Molecular weight
501.5
Formula
C24H26F3N7O2
Solubility
≥ 50·2mg/mL in DMSO
InChIKey
PWDLXPJQFNVTNL-UHFFFAOYSA-N
Catalogue number
GC14230
Brand
GLPBIO
Computed properties PubChem CID 11260561 · XLogP 2.8 · TPSA 109 Ų · H-bond donors 3
XLogP
2.8
TPSA
109 Ų
H-bond donors
3
H-bond acceptors
10
Rotatable bonds
6
Heavy atoms
36

SMILES CN1CCN(CC1)CC2=C(C=C(C=C2)NC(=O)NC3=CC=C(C=C3)OC4=NC(=NC=C4)N)C(F)(F)F

Computed descriptors from PubChem (CID 11260561), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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