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Chemical structure of Ruxolitinib

GC14191

Ruxolitinib

Also listed as Ruxolitinib (INCB18424)

Ruxolitinib (INCB018424), as an inhibitor, inhibits Janus-associated kinases (JAKs)JAK1 and JAK2 with IC50 values of 3·3 nM and 2·8 nM, respectively

ChemicalCAS941678-49-5MW306.37FormulaC17H18N6
CAS number
941678-49-5
Molecular weight
306.37
Formula
C17H18N6
Solubility
≥ 15·32mg/mL in DMSO
InChIKey
HFNKQEVNSGCOJV-OAHLLOKOSA-N
Catalogue number
GC14191
Brand
GLPBIO
Computed properties PubChem CID 25126798 · XLogP 2.1 · TPSA 83.2 Ų · H-bond donors 1
XLogP
2.1
TPSA
83.2 Ų
H-bond donors
1
H-bond acceptors
4
Rotatable bonds
4
Heavy atoms
23

SMILES C1CCC(C1)[C@@H](CC#N)N2C=C(C=N2)C3=C4C=CNC4=NC=N3

Computed descriptors from PubChem (CID 25126798), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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