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Chemical structure of PD184352 (CI-1040)

GC12989

PD184352 (CI-1040)

Also known as 2-(2-chloro-4-iodoanilino)-N-(cyclopropylmethoxy)-3,4-difluorobenzamide

PD184352 (CI-1040) (PD 184352) is an orally active, highly specific, small-molecule inhibitor of MEK with an IC50 of 17 nM for MEK1

ChemicalCAS212631-79-3MW478.67FormulaC17H14ClF2IN2O2
CAS number
212631-79-3
Molecular weight
478.67
Formula
C17H14ClF2IN2O2
Solubility
≥ 47·9mg/mL in DMSO
InChIKey
GFMMXOIFOQCCGU-UHFFFAOYSA-N
Catalogue number
GC12989
Brand
GLPBIO
Computed properties PubChem CID 6918454 · XLogP 5.6 · TPSA 50.4 Ų · H-bond donors 2
XLogP
5.6
TPSA
50.4 Ų
H-bond donors
2
H-bond acceptors
5
Rotatable bonds
6
Heavy atoms
25

SMILES C1CC1CONC(=O)C2=C(C(=C(C=C2)F)F)NC3=C(C=C(C=C3)I)Cl

Computed descriptors from PubChem (CID 6918454), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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