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Chemical structure of Cortistatin 14

GC12835

Cortistatin 14

Also known as (2S)-6-amino-2-[[(4R,7S,10S,13S,16S,19S,22S,25S,28S,31S,34S,37R)-19,34-bis(4-aminobutyl)-31-(2-amino-2-oxoethyl)-13,25,28-tribenzyl-16-[(1R)-1-hydroxyethyl]-7,10-bis(hydroxymethyl)-22-(1H-indol-3-ylmethyl)-6,9,12,15,18,21,24,27,30,33,36-undecaoxo-37-[[(2S)-pyrrolidine-2-carbonyl]amino]-1,2-dithia-5,8,11,14,17,20,23,26,29,32,35-undecazacyclooctatriacontane-4-carbonyl]amino]hexanoic acid

Cortistatin 14 (CST-14, human, rat), a neuropeptide with neuronal depressant and sleep modulating properties, can bind to all five cloned somatostatin receptors (SSTRs) and ghrelin receptor to exert its biological activities and co-exists with GABA within the cortex and hippocampus

ChemicalCAS193829-96-8MW1721.03FormulaC81H113N19O19S2
CAS number
193829-96-8
Molecular weight
1721.03
Formula
C81H113N19O19S2
Solubility
1mg/mL in water
InChIKey
DDRPLNQJNRBRNY-WYYADCIBSA-N
Catalogue number
GC12835
Brand
GLPBIO
Computed properties PubChem CID 16133803 · XLogP -2.7 · TPSA 676 Ų · H-bond donors 23
XLogP
-2.7
TPSA
676 Ų
H-bond donors
23
H-bond acceptors
25
Rotatable bonds
30
Heavy atoms
121

SMILES C[C@H]([C@H]1C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CCCCN)CC2=CNC3=CC=CC=C32)CC4=CC=CC=C4)CC5=CC=CC=C5)CC(=O)N)CCCCN)NC(=O)[C@@H]6CCCN6)C(=O)N[C@@H](CCCCN)C(=O)O)CO)CO)CC7=CC=CC=C7)O

Computed descriptors from PubChem (CID 16133803), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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