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Chemical structure of BLZ945

GC12539

BLZ945

Also known as 4-[[2-[[(1R,2R)-2-hydroxycyclohexyl]amino]-1,3-benzothiazol-6-yl]oxy]-N-methylpyridine-2-carboxamide

BLZ945 (BLZ945) is a potent, selective and brain-penetrant CSF-1R (c-Fms) inhibitor with an IC50 of 1 nM, showing more than 1,000-fold selectivity against its closest receptor tyrosine kinase homologs

ChemicalCAS953769-46-5MW398.48FormulaC20H22N4O3S
CAS number
953769-46-5
Molecular weight
398.48
Formula
C20H22N4O3S
Solubility
≥ 19·9mg/mL in DMSO
InChIKey
ADZBMFGQQWPHMJ-RHSMWYFYSA-N
Catalogue number
GC12539
Brand
GLPBIO
Computed properties PubChem CID 46184986 · XLogP 3.4 · TPSA 125 Ų · H-bond donors 3
XLogP
3.4
TPSA
125 Ų
H-bond donors
3
H-bond acceptors
7
Rotatable bonds
5
Heavy atoms
28

SMILES CNC(=O)C1=NC=CC(=C1)OC2=CC3=C(C=C2)N=C(S3)N[C@@H]4CCCC[C@H]4O

Computed descriptors from PubChem (CID 46184986), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.