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Chemical structure of NMS-1286937

GC12515

NMS-1286937

Also known as 1-(2-hydroxyethyl)-8-[5-(4-methylpiperazin-1-yl)-2-(trifluoromethoxy)anilino]-4,5-dihydropyrazolo[4,5-h]quinazoline-3-carboxamide

NMS-1286937 is a potent, selective and orally available PLK1 inhibitor, with an IC50 of 2 nM

ChemicalCAS1034616-18-6MW532.52FormulaC24H27F3N8O3
CAS number
1034616-18-6
Molecular weight
532.52
Formula
C24H27F3N8O3
Solubility
≥ 13·3mg/mL in DMSO
InChIKey
QHLVBNKYJGBCQJ-UHFFFAOYSA-N
Catalogue number
GC12515
Brand
GLPBIO
Computed properties PubChem CID 49792852 · XLogP 2 · TPSA 135 Ų · H-bond donors 3
XLogP
2
TPSA
135 Ų
H-bond donors
3
H-bond acceptors
12
Rotatable bonds
7
Heavy atoms
38

SMILES CN1CCN(CC1)C2=CC(=C(C=C2)OC(F)(F)F)NC3=NC=C4CCC5=C(C4=N3)N(N=C5C(=O)N)CCO

Computed descriptors from PubChem (CID 49792852), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.