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Chemical structure of Avutometinib

GC12406

Avutometinib

Also listed as RO5126766(CH5126766)

RO5126766(CH5126766) (CH5126766) is a first-in-class dual MEK/RAF inhibitor that allosterically inhibits BRAFV600E, CRAF, MEK, and BRAF (IC50: 8·2, 56, 160 nM, and 190 nM, respectively)

ChemicalCAS946128-88-7MW471.46FormulaC21H18FN5O5S
CAS number
946128-88-7
Molecular weight
471.46
Formula
C21H18FN5O5S
Solubility
Soluble in DMSO
InChIKey
LMMJFBMMJUMSJS-UHFFFAOYSA-N
Catalogue number
GC12406
Brand
GLPBIO
Computed properties PubChem CID 16719221 · XLogP 2 · TPSA 141 Ų · H-bond donors 2
XLogP
2
TPSA
141 Ų
H-bond donors
2
H-bond acceptors
11
Rotatable bonds
7
Heavy atoms
33

SMILES CC1=C(C(=O)OC2=C1C=CC(=C2)OC3=NC=CC=N3)CC4=C(C(=NC=C4)NS(=O)(=O)NC)F

Computed descriptors from PubChem (CID 16719221), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.