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Chemical structure of Selonsertib

GC12124

Selonsertib

Also listed as Selonsertib (GS-4997)

Selonsertib (GS-4997) (GS-4997), an orally bioavailable, selective apoptosis signal-regulating kinase 1 (ASK1) inhibitor with a pIC50 of 8·3, has been evaluated as an experimental treatment for diabetic nephropathy and kidney fibrosis

ChemicalCAS1448428-04-3MW445.49FormulaC24H24FN7O
CAS number
1448428-04-3
Molecular weight
445.49
Formula
C24H24FN7O
Solubility
≥ 44·5 mg/mL in DMSO, ≥ 88·8 mg/mL in EtOH
InChIKey
YIDDLAAKOYYGJG-UHFFFAOYSA-N
Catalogue number
GC12124
Brand
GLPBIO
Computed properties PubChem CID 71245288 · XLogP 2.7 · TPSA 90.5 Ų · H-bond donors 1
XLogP
2.7
TPSA
90.5 Ų
H-bond donors
1
H-bond acceptors
6
Rotatable bonds
6
Heavy atoms
33

SMILES CC1=CC(=C(C=C1N2C=C(N=C2)C3CC3)C(=O)NC4=CC=CC(=N4)C5=NN=CN5C(C)C)F

Computed descriptors from PubChem (CID 71245288), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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