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Chemical structure of AST-1306

GC11691

AST-1306

Also known as N-[4-[3-chloro-4-[(3-fluorophenyl)methoxy]anilino]quinazolin-6-yl]prop-2-enamide

AST-1306 (AST-1306) is an orally active and irreversible EGFR and ErbB2 inhibitor with IC50s of 0·5 and 3 nM, respectively· AST-1306 also inhibits ErbB4 with an IC50 of 0·8 nM· AST-1306 is an anilino-quinazoline compound and has anti-cancer activity

ChemicalCAS897383-62-9MW448.88FormulaC24H18ClFN4O2
CAS number
897383-62-9
Molecular weight
448.88
Formula
C24H18ClFN4O2
Solubility
≥ 22·45mg/mL in DMSO
InChIKey
MVZGYPSXNDCANY-UHFFFAOYSA-N
Catalogue number
GC11691
Brand
GLPBIO
Computed properties PubChem CID 24739943 · XLogP 5.4 · TPSA 76.1 Ų · H-bond donors 2
XLogP
5.4
TPSA
76.1 Ų
H-bond donors
2
H-bond acceptors
6
Rotatable bonds
7
Heavy atoms
32

SMILES C=CC(=O)NC1=CC2=C(C=C1)N=CN=C2NC3=CC(=C(C=C3)OCC4=CC(=CC=C4)F)Cl

Computed descriptors from PubChem (CID 24739943), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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