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Chemical structure of HPI 1

GC11045

HPI 1

Also known as 2-methoxyethyl 4-(3-hydroxyphenyl)-7-(2-methoxyphenyl)-2-methyl-5-oxo-4,6,7,8-tetrahydro-1H-quinoline-3-carboxylate

HPI 1 is a potent GLI antagonist with an IC50 value of 1·1 μM· HPI 1 shows anti-proliferative activity· HPI 1 decreases the GLI1 mRNA expression· HPI 1 inhibits colony formation in a dose-dependent manner

ChemicalCAS599150-20-6MW463.52FormulaC27H29NO6
CAS number
599150-20-6
Molecular weight
463.52
Formula
C27H29NO6
Solubility
DMSO ： 62·5 mg/mL (325·11 mM; Need ultrasonic)
InChIKey
ZXSWZQSYZYMZKS-UHFFFAOYSA-N
Catalogue number
GC11045
Brand
GLPBIO
Computed properties PubChem CID 2926768 · XLogP 3.3 · TPSA 94.1 Ų · H-bond donors 2
XLogP
3.3
TPSA
94.1 Ų
H-bond donors
2
H-bond acceptors
7
Rotatable bonds
8
Heavy atoms
34

SMILES CC1=C(C(C2=C(N1)CC(CC2=O)C3=CC=CC=C3OC)C4=CC(=CC=C4)O)C(=O)OCCOC

Computed descriptors from PubChem (CID 2926768), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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