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Chemical structure of IWR-1-endo

GC10950

IWR-1-endo

Also known as 4-[(1R,2S,6R,7S)-3,5-dioxo-4-azatricyclo[5.2.1.02,6]dec-8-en-4-yl]-N-quinolin-8-ylbenzamide

IWR-1-endo is a potent inhibitor of the Wnt response, blocking a cell-based Wnt/β-catenin pathway reporter response with an IC50 value of 180 nM

ChemicalCAS1127442-82-3MW409.44FormulaC25H19N3O3
CAS number
1127442-82-3
Molecular weight
409.44
Formula
C25H19N3O3
Solubility
≥ 20·45mg/mL in DMSO
InChIKey
ZGSXEXBYLJIOGF-ALFLXDJESA-N
Catalogue number
GC10950
Brand
GLPBIO
Computed properties PubChem CID 44483163 · XLogP 2.9 · TPSA 79.4 Ų · H-bond donors 1
XLogP
2.9
TPSA
79.4 Ų
H-bond donors
1
H-bond acceptors
4
Rotatable bonds
3
Heavy atoms
31

SMILES C1[C@@H]2C=C[C@H]1[C@@H]3[C@H]2C(=O)N(C3=O)C4=CC=C(C=C4)C(=O)NC5=CC=CC6=C5N=CC=C6

Computed descriptors from PubChem (CID 44483163), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.