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Chemical structure of Ivacaftor

GC10296

Ivacaftor

Also listed as Ivacaftor (VX-770)

Ivacaftor (VX-770) (VX-770) is a potent and orally bioavailable CFTR potentiator, targeting G551D-CFTR and F508del-CFTR with EC50s of 100 nM and 25 nM, respectively

ChemicalCAS873054-44-5MW392.49FormulaC24H28N2O3
CAS number
873054-44-5
Molecular weight
392.49
Formula
C24H28N2O3
Solubility
≥ 19·6mg/mL in DMSO, ≥ 2·95 mg/mL in EtOH with ultrasonic
InChIKey
PURKAOJPTOLRMP-UHFFFAOYSA-N
Catalogue number
GC10296
Brand
GLPBIO
Computed properties PubChem CID 16220172 · XLogP 5.6 · TPSA 78.4 Ų · H-bond donors 3
XLogP
5.6
TPSA
78.4 Ų
H-bond donors
3
H-bond acceptors
4
Rotatable bonds
4
Heavy atoms
29

SMILES CC(C)(C)C1=CC(=C(C=C1NC(=O)C2=CNC3=CC=CC=C3C2=O)O)C(C)(C)C

Computed descriptors from PubChem (CID 16220172), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.