GB40418
XIB4035
XIB4035 (10023-54-8) is a novel small molecule thought to be an agonist at the glial cell line-derived neurotrophic factor (GDNF) family receptor GFRα-1· It inhibits radiolabeled GDNF binding in Neuro-2A cells in a concentration dependent manner IC50 = 10·4 μM· Like GDNF, XIB4035 induced Ret autophosphorylation and promoted neurite outgrowth in Neuro-2A cells· Recent studies indicate that it enhances GFRα family receptor signaling in conjunction with ligand stimulation· Effective treatment for small-fiber neuropathy in mouse models of the disease· GDNF agonists may be a new class of Parkinson's disease therapeutics
ChemicalCAS10023-54-8MW750.45FormulaC26H31Cl2N3?3(H3PO4)
- CAS number
- 10023-54-8
- Molecular weight
- 750.45
- Formula
- C26H31Cl2N3?3(H3PO4)
- Catalogue number
- GB40418
- Brand
- GLPBIO
Ordering in Israel
- Lead time
- Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
- Pricing
- Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
- Documents
- Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
- Who we serve
- Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.
- Questions
- WhatsApp · +972-55-990-7576 · orders@labo.co.il