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Chemical structure of WX-132-18B

GB40412

WX-132-18B

Also known as 7-methoxy-4-(2-methylquinazolin-4-yl)-1,3-dihydroquinoxalin-2-one

WX-132-18B is a microtubule-depolymerizing agent that selectively acts on the colchicine-binding site of tubulin and exerts potent in vitro and in vivo anti-tumor effects· Specifically, WX-132-18B exhibited high in vitro cytotoxic activity (GI50 value of 1·9-3·2 nM), significant potency against tubulin assembly (IC50 value of 0·77 μM), and substantial inhibition of colchicine binding (99% at 5 μM)· Moreover, WX-132-18B caused cell arrest in G2/M phase

ChemicalCAS1415262-07-5MW320.35FormulaC18H16N4O2
CAS number
1415262-07-5
Molecular weight
320.35
Formula
C18H16N4O2
InChIKey
LTTPRSPHFQPOMT-UHFFFAOYSA-N
Catalogue number
GB40412
Brand
GLPBIO
Computed properties PubChem CID 71543088 · XLogP 2.9 · TPSA 67.4 Ų · H-bond donors 1
XLogP
2.9
TPSA
67.4 Ų
H-bond donors
1
H-bond acceptors
5
Rotatable bonds
2
Heavy atoms
24

SMILES CC1=NC2=CC=CC=C2C(=N1)N3CC(=O)NC4=C3C=CC(=C4)OC

Computed descriptors from PubChem (CID 71543088), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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