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Chemical structure of VU0486846

GB40406

VU0486846

Also known as (2R)-N-[(1S,2S)-2-hydroxycyclohexyl]-4-[(4-pyrazol-1-ylphenyl)methyl]-2,3-dihydro-1,4-benzoxazine-2-carboxamide

VU0486846 is a potent and highly selective M1 PAM (EC50 value of 0·31 μM, 85%), devoid of agonist activity in the PFC, as well as cholinergic or other adverse effects in mice, rats and NHP, which results in robust procognitive activity in rodent models

ChemicalCAS1788055-11-7MW432.51FormulaC25H28N4O3
CAS number
1788055-11-7
Molecular weight
432.51
Formula
C25H28N4O3
InChIKey
LZCHTDQRMCSDSE-ODGPQVTHSA-N
Catalogue number
GB40406
Brand
GLPBIO
Computed properties PubChem CID 118124117 · XLogP 3.3 · TPSA 79.6 Ų · H-bond donors 2
XLogP
3.3
TPSA
79.6 Ų
H-bond donors
2
H-bond acceptors
5
Rotatable bonds
5
Heavy atoms
32

SMILES C1CC[C@@H]([C@H](C1)NC(=O)[C@H]2CN(C3=CC=CC=C3O2)CC4=CC=C(C=C4)N5C=CC=N5)O

Computed descriptors from PubChem (CID 118124117), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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