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Chemical structure of SBI-183

GB40360

SBI-183

Also known as 3-methoxy-N-(4-pyrrolidin-1-ylphenyl)benzamide

SBI-183 is an orally active inhibitor of QSOX1 (Kd value of 20 μM), thereby suppressing the proliferative and invasive phenotype of two renal cancer cell lines (786-O and RCJ-41T2), a triple negative breast cancer (TNBC) cell line (MDA-MB-231), a lung adenocarcinoma cell line (A549), and a pancreatic ductal adenocarcinoma (MIA PaCa2)· Moreover, SBI-183 inhibits tumor growth in two independent human xenograft mouse models of renal cell carcinoma

ChemicalCAS625403-59-0MW296.36FormulaC18H20N2O2
CAS number
625403-59-0
Molecular weight
296.36
Formula
C18H20N2O2
InChIKey
ZZJGTLJERDOEQV-UHFFFAOYSA-N
Catalogue number
GB40360
Brand
GLPBIO
Computed properties PubChem CID 1121741 · XLogP 3.3 · TPSA 41.6 Ų · H-bond donors 1
XLogP
3.3
TPSA
41.6 Ų
H-bond donors
1
H-bond acceptors
3
Rotatable bonds
4
Heavy atoms
22

SMILES COC1=CC=CC(=C1)C(=O)NC2=CC=C(C=C2)N3CCCC3

Computed descriptors from PubChem (CID 1121741), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Documents
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Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.