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Chemical structure of Metapristone

GB40275

Metapristone

Also listed as Metapristone - RU42633 | Desmethylmifepristone

Metapristone, the primary metabolite of RU486 , suppressed NSCLC proliferation by promoting apoptosis via decrease the cellular EGFR-mediated PI3K/AKT pathways· In addition, metapristone inhibited anti-apoptotic marker Bcl-2, and activated pro-apoptotic key signaling proteins caspase-3, and poly (ADP-ribose) polymerase· Metapristone induced A549 and H1975 cell cycle via arrest at the G0-G1 stage· Moreover, metapristone inhibited endometrial cancer cell growth through suppressing cell proliferation and activating cell apoptosis-related signaling pathway· Mechanically, metapristone regulated miR-492 and its new target genes Klf5 and Nrf1 in vitro and in vivo to treat endometrial cancer

ChemicalCAS104004-96-8MW415.57FormulaC28H33NO2
CAS number
104004-96-8
Molecular weight
415.57
Formula
C28H33NO2
InChIKey
IBLXOBHABOVXDY-WKWWZUSTSA-N
Catalogue number
GB40275
Brand
GLPBIO
Computed properties PubChem CID 10070462 · XLogP 3.6 · TPSA 49.3 Ų · H-bond donors 2
XLogP
3.6
TPSA
49.3 Ų
H-bond donors
2
H-bond acceptors
3
Rotatable bonds
3
Heavy atoms
31

SMILES CC#C[C@@]1(CC[C@@H]2[C@@]1(C[C@@H](C3=C4CCC(=O)C=C4CC[C@@H]23)C5=CC=C(C=C5)NC)C)O

Computed descriptors from PubChem (CID 10070462), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.