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Chemical structure of LW 479

GB40266

LW 479

Also known as 6-[2-[2-(3-bromophenyl)-4-oxo-1,3-thiazolidin-3-yl]phenoxy]-N-hydroxyhexanamide

HDAC inhibitor that shows marked cytotoxicity and induces apoptosis as well as cell cycle arrest in a panel of breast cancer cell lines· LW479 silences EGFR expression in breast cancer cells through disrupting Sp1 and HDAC1 binding to EGFR promoter, and blocks EGF/EGFR signalling pathway and EGF-stimulated motility· Moreover, LW-479 attenuates breast cancer metastasis to the lung

ChemicalCAS1688677-89-5MW479.39FormulaC21H23BrN2O4S
CAS number
1688677-89-5
Molecular weight
479.39
Formula
C21H23BrN2O4S
InChIKey
XRAVVAITOQNASO-UHFFFAOYSA-N
Catalogue number
GB40266
Brand
GLPBIO
Computed properties PubChem CID 91900719 · XLogP 3.9 · TPSA 104 Ų · H-bond donors 2
XLogP
3.9
TPSA
104 Ų
H-bond donors
2
H-bond acceptors
5
Rotatable bonds
9
Heavy atoms
29

SMILES C1C(=O)N(C(S1)C2=CC(=CC=C2)Br)C3=CC=CC=C3OCCCCCC(=O)NO

Computed descriptors from PubChem (CID 91900719), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.