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Chemical structure of KL101

GB40252

KL101

Also known as N-[2-(2,4-dimethylphenyl)-4,6-dihydrothieno[3,4-c]pyrazol-3-yl]-3,4-dimethylbenzamide

KL101 (396721-89-4) is an isoform-selective stabilizer of the circadian clock protein CRY1· It dose-dependently lengthened the circadian period in Bmal1-dLuc and Per2-dLuc reporter cells· KL101 strongly enhanced rosiglitazone-dependent brown adipocyte differentiation revealing the importance of CRY-dependent regulation of energy metabolism and a possible new lead for anti-obesity therapeutics

ChemicalCAS396721-89-4MW377.51FormulaC22H23N3OS
CAS number
396721-89-4
Molecular weight
377.51
Formula
C22H23N3OS
InChIKey
FJKKXWLUKJOWNU-UHFFFAOYSA-N
Catalogue number
GB40252
Brand
GLPBIO
Computed properties PubChem CID 4626654 · XLogP 4.6 · TPSA 72.2 Ų · H-bond donors 1
XLogP
4.6
TPSA
72.2 Ų
H-bond donors
1
H-bond acceptors
3
Rotatable bonds
3
Heavy atoms
27

SMILES CC1=CC(=C(C=C1)N2C(=C3CSCC3=N2)NC(=O)C4=CC(=C(C=C4)C)C)C

Computed descriptors from PubChem (CID 4626654), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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