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Chemical structure of JMJD6 inhibitor WL12

GB40246

JMJD6 inhibitor WL12

Also known as 3-(3H-imidazo[4,5-c]pyridin-2-yl)-6-methylchromen-2-one

JMJD6 inhibitor WL12 is a first-in-class JMJD6 inhibitor with an IC50 value of 0·22 μM· JMJD6 inhibitor WL12 was shown to be able to suppress JMJD6-dependent cancer cell proliferation including cervical and liver cancer cells· Specifically, the IC50 values for JMJD6 inhibitor WL12 in HeLa and SMCC7721 cells were 2·44 and 10·18 μM, respectively

ChemicalCAS899548-78-8MW277.28FormulaC16H11N3O2
CAS number
899548-78-8
Molecular weight
277.28
Formula
C16H11N3O2
InChIKey
AFTXOIIKGOXDOT-UHFFFAOYSA-N
Catalogue number
GB40246
Brand
GLPBIO
Computed properties PubChem CID 22424483 · XLogP 2.4 · TPSA 67.9 Ų · H-bond donors 1
XLogP
2.4
TPSA
67.9 Ų
H-bond donors
1
H-bond acceptors
4
Rotatable bonds
1
Heavy atoms
21

SMILES CC1=CC2=C(C=C1)OC(=O)C(=C2)C3=NC4=C(N3)C=NC=C4

Computed descriptors from PubChem (CID 22424483), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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