Loading...
Chemical structure of iCRT5

GB40238

iCRT5

Also known as 4-[(5Z)-5-[(3,4-dimethoxyphenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]butanoic acid

iCRT5 (18623-44-4) is a selective CRT (β-catenin-responsive transcription) inhibitor· IC50=18 nM for Wnt responsive STF16 luciferase· Acts via interfering with the β-catenin, TCF4 interaction· Displays poor inhibition of cell proliferation in triple-negative breast cancer cells· Increases the surface expression of MHCII, CD80 and CD86 on unstimulated dendritic cells (DCs) with no detrimental effects on immune-phenotype of stimulated DCs· Modulators of Wnt signaling show great promise in animal models of several cancers· Cell permeable

ChemicalCAS18623-44-4MW367.44FormulaC16H17NO5S2
CAS number
18623-44-4
Molecular weight
367.44
Formula
C16H17NO5S2
InChIKey
IJWKSBPTJQMUHJ-LCYFTJDESA-N
Catalogue number
GB40238
Brand
GLPBIO
Computed properties PubChem CID 1416325 · XLogP 2.8 · TPSA 133 Ų · H-bond donors 1
XLogP
2.8
TPSA
133 Ų
H-bond donors
1
H-bond acceptors
7
Rotatable bonds
7
Heavy atoms
24

SMILES COC1=C(C=C(C=C1)/C=C\2/C(=O)N(C(=S)S2)CCCC(=O)O)OC

Computed descriptors from PubChem (CID 1416325), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.