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Chemical structure of Exo2

GB40194

Exo2

Also known as 2-methoxy-4-[(5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-ylhydrazinylidene)methyl]phenol

Exo2 (304684-77-3) disrupts the Golgi apparatus and stimulates Golgi-ER fusion in mammalian cells· May be used to completely ablate the Golgi apparatus· Like brefeldin A (BFA), it inhibits anterograde transport and disrupts morphology of the trans-Golgi network (TGN) but unlike BFA, it does not induce tubulation and merging of the TGN and endosomal compartments· It perturbs trafficking of Shiga toxin between endosomes and the trans-Golgi network, in contrast to cholera toxin· Accelerates degradation of perilipin-2 proteins

ChemicalCAS304684-77-3MW354.43FormulaC18H18N4O2S
CAS number
304684-77-3
Molecular weight
354.43
Formula
C18H18N4O2S
InChIKey
VFNUTEMVQGLDAG-UHFFFAOYSA-N
Catalogue number
GB40194
Brand
GLPBIO
Computed properties PubChem CID 4040780 · XLogP 4.3 · TPSA 108 Ų · H-bond donors 2
XLogP
4.3
TPSA
108 Ų
H-bond donors
2
H-bond acceptors
7
Rotatable bonds
4
Heavy atoms
25

SMILES COC1=C(C=CC(=C1)C=NNC2=C3C4=C(CCCC4)SC3=NC=N2)O

Computed descriptors from PubChem (CID 4040780), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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